Hatton was taken to hospital following his brutal two-round demolition by Pacquiao nearly three weeks ago and is now considering his future.
It was Mayweather who inflicted Hatton’s first career loss in 2007 with the American then entering a spell of retirement that will end when he meets Juan Manuel Marquez in Las Vegas on July 18.
Speaking in London to promote his fight with Marquez, Mayweather claimed Hatton had already taken too much punishment and also criticised his lifestyle in between fights.
“Ricky’s career was over in 2007 when he met me,” said Mayweather.
“He was a gutsy, tough champ but there’s a time in every boxer’s career when they must hang it up.
“He was knocked out bad twice – by me and Pacquiao. He’s been in a lot of tough fights and taken some big shots.
“Gaining weight and drinking – you can’t have that sort of lifestyle in boxing. You have to take your job seriously.
“I don’t think Ricky should fight again. I wouldn’t fight him again, even at Wembley.
“It would be like picking on a guy that we call ‘gun-shot, gun-shot’.
“Once you’ve been knocked out in the way he was by me, it’s always in the back of your mind that it can happen again. His head won’t be the same.”
Hatton’s training camp in the build up to the Pacquiao fight was undermined by a deteriorating relationship with Mayweather Sr.
Reports claim Mayweather Sr consistently arrived late for training and failed to show up on the night of the fight until Hatton was having his hands bandaged.
But Mayweather Jr insisted Hatton only had himself to blame.
“That fight wasn’t my father’s gameplan,” he said. “I don’t want everyone over here ripping my father to shreds. It wasn’t his fault. My dad told him to go out, relax, use his jab and be smart. It wasn’t my dad’s fault.
“A lot of the time trainers try to tell fighters what to do without having been in combat. My dad has been in combat before.”
Mayweather, a defensive genius, was reluctant to talk about his own collision-course with Pacquiao.
The credentials of Mexican great Marquez are immaculate but public opinion demands Mayweather meets the man who succeeded him as pound-for-pound king.
When pressed the 32-year-old made it clear he views the Filipino as very beatable. “If the Pacquiao fight presents itself after this one, then I’ll lay the blueprint on how to beat him,” said Mayweather. “Pacquiao’s a good fighter but he can be got. He was knocked out twice. I’m a slick, smart boxer and would tie him up.”