The Bills’ loss after four wins left the NFL with only two undefeated teams — the Tennessee Titans (5-0) and the New York Giants (4-0).
Buffalo completed all but three plays without starting quarterback Trent Edwards, who suffered a concussion early in the game and did not return. He was replaced by JP Losman.
Meanwhile, Arizona paved the way for victory by scoring on itstheir first three possessions.
Kurt Warner passed for two touchdowns and Tim Hightower ran for two more as the Cardinals won for the third time in five games.
Warner connected with Larry Fitzgerald on a two-yard scoring play in the third quarter to start the run of 17 successive points by the Cardinals.
The pair also teamed up for Arizona’s first touchdown on another two-yard play in the first quarter.
Peyton Manning helped spearhead one of several stunning turnarounds, while brother Eli led defending Super Bowl champion New York to victory over Seattle.
Indianapolis Colts star Peyton Manning helped his club rally from a 17 point deficit on Sunday with a five-year touchdown pass to Reggie Wayne with just under two minutes left in the fourth quarter to put the finishing touches on a 31-27 win over the Houston Texans. “It didn’t look good,” said Manning. “We came here wanting to take the crowd out of it. Houston did a good job of fighting back. We put ourselves in a hole. We can’t afford to be behind right now because teams are doing a good job of running the clock.’’
“We were sitting there, saying we needed three scores and wondering if we would have enough time.”
After trailing 10-0 after the first period, Houston scored 27 straight points and seemed to be in control with a 27-10 lead. But the Texans unravelled as quarterback Sage Rosenfels fumbled on consecutive possessions.
After Manning threw a seven-yard touchdown pass to Tom Santi with just over four minutes left, Rosenfels ill-advisedly tried to dive for a first down. He lost the ball and linebacker Gary Brackett returned the fumble 68 yards for a touchdown.
On Houston’s next possession, defensive end Robert Mathis stripped Rosenfels and the Colts (2-2) recovered at the Texans’ 20, setting up Manning’s go-ahead score. Peyton’s brother, Eli, tossed two touchdown passes and Brandon Jacobs romped into the endzone for two others as the Giants spanked Seattle 44-6.
The Giants improved to 4-0 despite not having Plaxico Burress, the Giants’ top wide receiver and Manning’s favourite target for the past three-plus seasons. In Baltimore, the Titans remained unbeaten with a 5-0 record by coming from behind to beat the Ravens.
Kerry Collins tossed an 11-yard touchdown pass to Alge Crumpler with 1:56 left as the Titans won 13-10 against Baltimore.
In other games Carolina blanked Kansas City 34-0, Chicago defeated Detroit 34-7, Atlanta edged Green Bay 27-24, Miami beat San Diego 17-10, Washington stopped Philadelphia 23-17, Denver defeated Tampa Bay 16-13, Arizona trounced Buffalo 41-17, New England beat San Francicsco 30-21 and Pittsburgh edged Jacksonville 26-21