Hitting the ball with supreme power, the diminutive India batsman, employed as a makeshift opener during this four-match series, dominated the day's scoring as the second Test got under way.
He eventually fell for 106 bowled by Craig White out of India's 179 for four, having brought up his three figures in the 54th over.
In doing so, he provided his one and only chance a half-chance at that as Michael Vaughan stretched high to his left to get his hand on a thunderous square-drive which, nevertheless, provided a 17th boundary.
Anything short or wide was punished as all but the impressive Matthew Hoggard suffered.
Sehwag's aggressive tendencies also allowed India to consolidate after Sachin Tendulkar chopped a Dominic Cork long-hop into his stumps, to leave the touring side vulnerable on a score of 108 for three.
Tendulkar, who has taken some stick back home for his performance in the first Test defeat at Lord's, appeared set to deliver his retribution on England, patiently compiling his 34.
Hoggard now rated fifth in the official world Test bowling standings made early inroads but was the only one to utilise the cloud cover overhead.
Swinging the ball prodigiously throughout his opening spell, he found success from his eighth delivery of the morning when Wasim Jaffer was drawn into a drive and inside-edged into his stumps.
Sehwag, whose one moment of good fortune arrived in the second over of the day when he jabbed down on a Dominic Cork delivery which bounced over the stumps, flailed front-foot boundaries through the off-side whenever the opportunity allowed and displayed sound judgment of when to leave alone outside off-stump.
But another out-swinger from Hoggard nicked the edge of Rahul Dravid's bat and debutant Robert Key took a knee-high catch falling to his right at first slip.
VVS Laxman, India's most impressive batsman at Lord's, played some glorious strokes to race to 22 when umpires Russell Tiffin and Rudi Koertzen consulted their light meters once again at 5pm.
And as had been the case before tea, Ganguly decided to accept the offer to leave the field with two lights showing on the scoreboard, which read 210 for four.