Drug for weight loss could be ‘holy grail’

Lorcaserin is the first weight loss drug deemed safe for heart health

Drug for weight loss could be ‘holy grail’

Lorcaserin is the first weight loss drug deemed safe for heart health

A weight loss pill has been hailed as a potential holy grail in the fight against obesity after a study showed it does not increase the risk of serious heart problems.

Researchers say lorcaserin is the first weight-loss drug to be deemed safe for heart health with long-term use, which could see regulators approve it for prescription on the NHS.

Taken twice a day, the drug is an appetite suppressant which works by stimulating brain chemicals to induce a feeling of fullness.

A US study saw 12,000 people who were either obese or overweight given the pills or a placebo — with those who took the drug shedding an average of 4kg in 40 months.

Further analysis showed no big differences in tests for heart valve damage.

Tam Fry of Britain’s National Obesity Forum said that the drug is potentially the “holy grail” of weight-loss medicine.

“I think it is the thing everybody has been looking for,” said Mr Fry.

I think there will be several holy grails, but this is a holy grail and one which has been certainly at the back of the mind of a lot of specialists for a long time. But all of the other things apply — lifestyle change has got to be root and branch part of this.

The Food and Drug Administration, the US medicines watchdog, approved lorcaserin’s use in some adults in 2012.

The drug has been on sale there since 2013, where it costs €170 to €250 a month.

The study into its long-term effects was led by Erin Bohula, a cardiovascular medicine analyst at the Harvard-affiliated Brigham and Women’s Hospital.

Dr Bohula said: “Patients and their doctors have been nervous about using drugs to treat obesity and for good reason. There’s a history of these drugs having serious complications.”

As well as affecting the heart, there are concerns weightloss drugs can lead to mental health issues.

The results of the study were discussed at the European Society of Cardiology in Munich, Germany, on Sunday and have been published by the New England Journal of Medicine.

The researchers found after one year 39% of participants given lorcaserin had lost at least 5% of their starting weight, compared with 17% of those given placebo.

Analysis also showed fewer people taking lorcaserin developed diabetes, 8.5% compared with 10.3% on placebo.

Tests for heart valve damage were done on 3,270 participants, but no significant differences in rates were identified.

Suicidal thoughts or behaviour were reported in 21 people taking lorcaserin compared with 11 people given a placebo.

However, those taking the weight loss drug had a history of depression.

The researchers said: “Among overweight or obese patients with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors who were being treated with dietary and exercise interventions, those who received lorcaserin had better long-term rates of weight loss than those who received placebo at a median follow-up of 3.3 years.

“The higher weight-loss rates were achieved without an accompanying increase in the risk of cardiovascular events.”

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