The largest ever study of transgender people in Ireland claims 40% have attempted suicide at least once.
Mental health is expected to top the agenda at the country's first ever Transgender Healthcare Conference later.
Some 78% of participants reported thinking about ending their lives. Participants also reported common experiences of stress (83%), depression (82%) and anxiety (73%).
In a survey of 793 HSE professionals, 90% of respondents stated that they had not had any training on trans issues and 74% of respondents indicated that they would like training in this area.
"Transgender people are part of Irish society and it is essential that our services address their needs," said Dr Philip Crowley, HSE National Director, the Quality Improvement Division.
"To do this, the HSE is in the process of developing services and models of care which will involve building capacity at national and local levels. This will also require targeted investment."
"For many trans people, medical transitioning is life saving," continued Ms. Lacey.
"We need holistic, comprehensive health care services for trans people. This conference is an incredibly positive step in that direction."