Working alongside city officials, gardaí and nightclub owners are set to tackle drug use, underage drinking, binge drinking and the use of fake ID cards amongst the 3,000 revellers who spill into the city's streets each weekend.
They also plan to use more CCTV cameras outside nightclubs as well as special shuttle bus services directly outside clubs in the run-up to Christmas. They will be working in conjunction as part of their new Safe Home Partnership initiative.
City superintendent Michael McGarry said the campaign had arisen out of safety concerns for young people seeking to enjoy a night out.
"The gardaí has a statutory responsibility to maintain public order and we welcome all properly organised and sustained initiatives that support us in our work.
The Waterford Safe Home Partnership represents a genuine commitment to make Waterford the safest and best city in Ireland for a night-out.
"The initiative is broadly based and is representative of all the main stakeholders the hospitality and entertainment industry, the gardaí and the Waterford community represented by the mayor and the city council," added Superintendent McGarry.
Nightclub owner Bob Tweedy, one of the prime movers behind the initiative, said the hospitality industry and nightclub owners in Waterford were united in ensuring high standards of customer care.
"We have already made very substantial financial investments in ensuring the levels of safety, comfort and entertainment available to them are of the highest standard. However, we must be realistic and recognise while we can constantly monitor the quality of service and the security delivered inside our premises, we are limited in ensuring that what happens outside in the streets is up to the high standards we require," he said.
Waterford Mayor Alderman Tom Cunningham also welcomed the initiative which he said will allow the public "walk the streets in safety at all times of the day and night".