The hatred the Lancashire neighbours’ feel for each other is probably borne out of the incredible similarities between the two industrial cities.
Liverpool Port was once a bustling trade dock until the Manchester ship canal was built in the 1890s, taking much of that business away.
Just 32 miles apart, both cities have always had thriving cultural and arts scenes and between them they have continually set the tone for British pop culture.
This is where the rivalry emanates from, but it manifests itself on the pitch and in the stands year after year.
Liverpool are the most successful English team on the continent with five European titles to United’s three.
United are stronger domestically with a record 20 league titles to Liverpool's 18.
No game in English football can match the intensity of this one.
Sunday in Manchester will be no different.
Here’s a selection of the greatest games in modern times to take place between the rivals at Old Trafford.
The return of Eric Cantona for United after his eight month ban for kung fu kicking a fan was all anybody wanted to talk about, but Robbie Fowler made an attempt to steal the show with two strikes to put Liverpool 2-1 in front. When Ryan Giggs won a penalty, Cantona coolly converted and the headlines went to the Frenchman.
A Michael Owen goal left Liverpool on the brink of an FA Cup third round win. As Andy Gray said to Martin Tyler on Sky Sports as the minutes ticked away; “I’m telling you, it’s Liverpool’s day”.
Two exceptionally late goals from Dwight Yorke and Ole Gunnar Solskjaer proved Gray wrong. It was to become a recurring theme for United that season.
Liverpool didn’t really stand a chance once Sami Hyppia was sent off in the opening exchanges for hauling down Ruud van Nistelrooy. What followed was a rare battering for the Merseysiders.
A Cristiano Ronaldo penalty looked like giving United’s star studded Champions League winning side a free pass to an easy afternoon.
However, Fernando Torres had different ideas and terrorised the normally unflappable United defender Nemanja Vidic simply by running at him at speed every time he got the ball. The Serbian was sent off later in the game.
Liverpool were 2-1 up at half-time and completed the route in the second half.
While Liverpool had got the better of United in this one-off game, in a role reversal of the ‘80s, the Mancunians went on to win the title.
The end of the David Moyes era was nearing and this was one of the most inept performances by a United team against Liverpool at Old Trafford ever.
The Merseysiders were first to the ball on every occasion, won every 50-50 and bypassed Marouane Fellaini so easily he resembled a totem pole in United’s midfield.
Three penalties, one missed ,and a Luis Suarez goal left United fans calling for Moyes’ head. They soon got their wish.
So, who will come out on top on Sunday?