Knox, who is American, was convicted and imprisoned in Italy, with Raffaele Sollecito, for the 2007 murder of Kercher. After appeals and retrials, they were acquitted last year by Italy’s highest court.
Titled Amanda Knox, the documentary will premiere at the Toronto International Film Festival next month, before a global launch on September 30.
The case, which made headlines around the world, has previously been the subject of the documentary, A Long Way From Home, and TV movie, Amanda Knox: Murder On Trial In Italy, with Hayden Panettiere in the title role.
Netflix is planning to unveil three other non-fiction titles at TIFF, before making them available to subscribers online in the autumn.
Leonardo DiCaprio is executive producing “thriller” documentary, The Ivory Game, which take viewers to the front lines of the fight to save the African elephant from extinction.
It was filmed undercover for 16 months, with the help of intelligence operatives, undercover activists, rangers and conservationists, infiltrating the global ivory-trafficking network.
Werner Herzog and volcanologist, Clive Oppenheimer’s Into The Inferno is about volcanoes, while The White Helmets follows three volunteer rescue workers in Syria and Turkey in early 2016, as they try to save civilians affected by the war.
Lisa Nishimura, Netflix vice-president of original documentary programming, said: “The breadth of our slate at the Toronto International Film Festival speaks to Netflix’s continued celebration of diverse voices and styles in the world of non-fiction.
“We are committed to pushing the boundaries of the documentary form, and our films screening at Toronto represent both emerging talent and iconic film-makers, during a thrilling time for documentaries.”