Madeleine McCann was just three when she disappeared from the family’s holiday apartment in Praia da Luz in Portugal in May 2007.
Ms McCann, of Rothley, Leicestershire, vowed she and her husband Gerry, who also have 10-year-old twins, would “never give up” hope of finding their daughter.
The 47-year-old, who is an ambassador for the charity Missing People, said her research had led her to believe abducted children were not usually taken far from the scene.
She told The Sun: “That’s where she last was and I don’t think she’s been taken a million miles from there. I’ve always said Praia da Luz is the place where I feel closest to her.
“It’s all only speculation, but we’ve learned that’s usually the case.
“The urge to look for Madeleine absolutely hasn’t changed at all. You hear all the time about people who have been missing for years being found.
“There have been so many cases like that.
“We will never give up. You couldn’t settle if you thought about giving up. I want an end, an answer. Whatever that it is.”
Ms McCann added that Child Rescue Alerts, a scheme of early warning messages she helped launch, could have “mobilised” people at the time of Madeleine’s disappearance.
Since 2011, the Metropolitan Police have been assisting in the search for clues as to what happened to the girl with officers visiting the holiday resort in 2014.
The couple had previously praised the “meticulous and painstaking work” of detectives, and have again offered thanks to the police.
"But last year the number of officers working on the case was reduced.
"The British Home Office said in June the investigation had cost £10m, with a further £2m budgeted for the year ahead.
Detectives have taken 1,338 statements and collected 1,027 exhibits.