New treatment of depression in cancer patients has had promising results

Two trials testing a new approach to managing depression in cancer patients, which is often overlooked or ignored, have shown positive results.

A survey of more than 21,000 patients in Scotland found rates of clinical depression ranging from 6% to 13% among cancer patients, compared with a prevalence of just 2% in the general population.

Of the 1,130 who had been diagnosed, almost three quarters (73%) were not receiving any kind of effective treatment.

woman with her head in her hands as women aged 55 and younger are twice as likely to suffer a heart attack or die young
(David Cheskin/PA)

SMaRT (Symptom Management Research Trials) Oncology 2 and 3 used specially-trained nurses to deliver a range of psychiatric care including behavioural therapies and medication.

Oxford University’s Professor Michael Sharpe, one of the researchers whose findings are reported in the journal The Lancet Psychiatry, said: “We’ve described a new approach to managing depressed cancer patients that is based on the short-comings of usual care and integrated with cancer care that really has quite spectacular effects in the good prognosis patients and also has efficacy in the poor prognosis patients.”

The new treatment approach, costing £600, involves talking to patients, helping them to be active and engaged, “problem solving therapy” aimed at putting people more in control of their situation, and intensive monitoring for up to a year.

 Cancer survivors Anna Smiles, 26, Parminder Sangha, 29, Linda Seal, 61 and Adam Hart, 33 have their bodies painted by make-up artist Carolyn Roper as part of a Ã?human billboardÃ? to launch Cancer Research UKÃ?s Beat Cancer Sooner campaign, at Victoria Station
A Cancer Research UK human billboard (Matt Alexander/PA)

Patients randomly recruited to the programme had their progress compared with those who continued to undergo “usual care”. This generally involves GPs being in charge and prescribing antidepressants or referring patients to mental health services if necessary. It also usually means a patient has to seek help before it is given.

For 500 patients with a good cancer prognosis, 17.3% of those getting usual care saw a significant improvement in their scores of depression symptoms after six months. But 62% of those allocated the new therapy programme experienced a similar positive outcome – a difference of 45%.

As well as not feeling so depressed they were also less anxious, less fatigued, less afflicted by pain, and their quality of life was greatly enhanced. The difference in improvement was sustained for the whole of the 12 month follow-up period.

model posing with a stethoscope
(Andrew Matthews/PA)

The second trial, SMaRT Oncology 3, focused over a period of 32 weeks on patients with lung cancer who had a poor prognosis. Depression severity was found to be “significantly lower” in those assigned to the new treatment compared with those undergoing “usual care”.

Self-rated levels of depression improvement, anxiety and quality of life were all better for patients who continued to respond to the new treatment for 12 weeks.

“One of the biggest barriers we have to overcome is people thinking being depressed is part and package of cancer,” said Sharpe.

 radiation oncologist Dr. Wendy Woodward at MD Anderson to plan Suggs radiation therapy in Houston
(Marie D. De Jesus/AP)

All the patients had participated in routine screening for depression in Scottish cancer clinics between May 2008 and August 2011.

Those with lung cancer had the highest prevalence of major depression (13.1%) followed by patients with gynaecological cancers (10.9%) and breast cancer (9.3%).

Seven per cent of patients with bowel cancer were seriously depressed, as were 5.6% of individuals with genito-urinary cancers.

 mammogram showing a woman's breast as total darkness at night time is key to the success of breast cancer therapy
(Rui Vieira/PA)

SMaRT Oncology 3 leader Dr Jane Walker, from Oxford University, said: “Patients with lung cancer often have a poor prognosis. If they also have major depression that can blight the time they have left to live. This trial shows that we can effectively treat depression in patients with poor prognosis cancers like lung cancer and really improve patients’ lives.”

Funding for the studies came from Cancer Research UK and the Chief Scientist Office of the Scottish Government.

Macmillan cancer support bus

Jacqui Graves, head of health and social care at the charity Macmillan Cancer Support, said: “Depression may be a temporary reaction to a patient’s diagnosis and something that can be addressed through information and support, but in other cases it can be more complex and a patient may need therapy or medication.

“Anyone experiencing depression should get in touch with their GP. Macmillan provides information and support for people affected by cancer through its telephone helpline.”

The charity’s Support Line can be contacted on 0808 808 0000.

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