Cork City will begin their defence of the FAI Cup away from home.
The holders have been drawn against non-league Dublin side Home Farm.
Last year's beaten finalists will welcome Cobh Ramblers to Oriel Park while there is an all-Premier Division tie between Drogheda United and Shamrock Rovers.
There is a local derby in Inchicore as three-time cup winners St Patrick's Athletic travel to take on Leinster Senior League side Inchicore Athletic.
Ulster Senior League side Cockhill Celtic face a difficult challenge against Limerick while Skerries Town will take on high-flying Waterford.
All ties will be played between August 10 and 12.
📣 The Irish Daily Mail FAI Senior Cup First Round draw is below!#FAICup 🏆 Champions @CorkCityFC will travel to @Homefarm_FC in the first round!— FAIreland ⚽️🇮🇪 (@FAIreland) July 4, 2018
All fixtures set to be played the week ending August 12th! pic.twitter.com/6RH1wVLNtR