Dries Mertens scored twice as Napoli beat Bologna 3-1 to reclaim top spot in the Serie A table from reigning champions Juventus.
Following a 2-0 Bianconeri victory over Chievo on Saturday night, long-time leaders Napoli needed a quick response, but instead former Inter Milan striker Rodrigo Palacio gave Bologna a first-minute lead.
Bologna defender Ibrahima Mbaye obliged with the equaliser as he put through his own net in comic fashion just four minutes later.
Adam Masina fouled Jose Callejon to concede a penalty that Mertens tucked away eight minutes before the break and just before the hour the Belgian winger turned home an assist from Lorenzo Insigne.
Third-placed Lazio slipped further behind the top two after their six-game unbeaten run was ended by a 2-1 defeat at AC Milan.
Milan midfielder Giacomo Bonaventura scored the winner at San Siro, heading home a minute before the break to earn Gennaro Gattuso's men a third successive victory.
Italy Under-21 forward Patrick Cutrone had earlier nodded Milan ahead before they were quickly pegged back by a fine finish from Lazio midfielder Adam Marusic.
Sunday's shock result came in Florence, where lowly Hellas Verona pulled off a 4-1 triumph that featured a brace from Juve loanee Moise Kean.
Jagos Vukovic got the ball rolling in Tuscany and Kean, still just 17, bagged either side of the break to take the game away from mid-table Fiorentina. They did reply through Gil Dias, but Alex Ferrari confirmed a joyous end to Verona's four-game losing streak.
In the early game, a last-gasp Alberto Paloschi header saw strugglers SPAL force a 1-1 draw with Inter, who had gone ahead early in the second half through a Francesco Vicari own goal.
Hellas and SPAL remain in the relegation zone despite positive results, but they will just be grateful they are not basement boys Benevento, who were thrashed 3-0 at Torino.
Iago Falque fired a third-minute opener and, once Benevento lost goalkeeper Vid Belec to a red card, the floodgates were open and improving Torino pulled further clear thanks to Mbaye Niang and Joel Obi.
Elsewhere, Udinese shook off the dismissal of Samir to edge past Genoa 1-0 with a goal from Valon Behrami and Crotone and Cagliari shared the points from a 1-1 draw at Stadio Ezio Scida.
Marcello Trotta gave Crotone the upper hand before the half-hour mark, but Cagliari reacted to a red card for Fabio Pisacane by levelling through Luca Cigarini deep into first-half stoppage time.
Atletico Madrid eased past Las Palmas to strengthen their grip on second place in LaLiga.
The 3-0 win moves Atleti six points clear of Valencia as Diego Simeone's men remain the closest challengers to runaway leaders Barcelona.
Antoine Griezmann and Fernando Torres eventually broke down the visitors after the pair had both to come close to opening the scoring in the early stages, with Thomas adding the third late on.
Torres shot just wide at the midway point of the first-half, with Griezmann rattling the crossbar moments later with a tremendous effort.
The France international broke the deadlock with a tidy finish just after the hour-mark before hitting the woodwork again.
The lead was doubled courtesy of Torres before Thomas wrapped up the victory as Las Palmas were unable to offer much of an attacking threat throughout.
Earlier, Leganes - who triumphed over Real Madrid in the quarter-final of the Copa del Rey in the week - picked up a third successive home league win.
Espanyol were on the receiving end this time around as defender Mario Hermoso scored two own goals before pulling back a late consolation as the hosts won 3-2.
Hermoso's first own goal came early on and separated the sides at the interval, with Marc Navarro levelling soon after the restart.
Miguel Angel Guerrero re-established the lead for Leganes before Hermoso again turned past his own goalkeeper.
The former Real Madrid youngster netted at the right end with two minutes remaining but Espanyol, who remain 14th in the table, could not muster up a dramatic equaliser.
Leganes missed out on moving into the top-half of the table as Getafe scored a stoppage-time equaliser at Sevilla later in the evening.
In a closely-fought contest, Luis Muriel's second-half flick was looked enough to secure three points in Sevilla's hunt for European qualification.
But, after Ever Banega hit the post late on for the hosts, they were pegged back as Angel struck in the dying embers.
In-form Bayer Leverkusen climbed to second in the Bundesliga following a 2-0 success at home to Mainz.
After a goalless first half at BayArena, Leverkusen - who began the day in sixth - went ahead three minutes into the second period when Leon Bailey cut in from the right to curl home left-footed from 25 yards.
Heiko Herrlich's side had lost just one of their previous 14 league matches ahead of kick-off and they secured another victory in the 68th minute thanks to a penalty converted by Brazilian defender Wendell.
The win leaves Leverkusen 16 points adrift of runaway leaders Bayern Munich.
In Sunday's second game, Wolfsburg ended their five-game winless streak by securing a 1-0 success at near-neighbours Hannover.
Turkey midfielder Yunus Malli scored the only goal, firing into the roof of the net 18 minutes from time.
The hosts came close to a late equaliser but Ihlas Bebou crashed his close-range shot against the crossbar in the 86th minute.
Bordeaux's sought-after forward Malcom won and converted a disputed penalty as second-placed Lyon suffered a surprise 3-1 defeat in Ligue 1.
The Brazilian - linked with Premier League rivals Tottenham and Arsenal this month - threw himself to the ground inside the box under pressure from Lyon defender Jeremy Morel before putting the hosts 2-0 up with the resulting 27th-minute spot-kick.
Replays showed Morel had made no contact but that did not stop referee Francois Letexier pointing to the spot, five minutes after Bordeaux forward Nicolas De Preville had put the home side ahead.
Lyon bounced back from their misfortune and looked to have given themselves hope for the second half when defender Marcelo halved the deficit a minute before the break.
But Bordeaux, under new manager Gus Poyet, restored their two-goal cushion thanks to a second penalty, scored by Gaetan Laborde in first-half stoppage time, and then held on for victory following Otavio's 76th-minute dismissal for two bookable offences.
Earlier in the day, Edgar Ie scored a dramatic stoppage-time winner as struggling Lille moved out of the relegation zone with a 2-1 success over Strasbourg.
Portugal defender Ie converted at the near post following a corner a minute into added time to claim his first goal since moving to French football from Belenenses last summer.
Algeria forward Idriss Saadi looked to have earned Strasbourg a point when he quickly cancelled out Anwar El Ghazi's 76th-minute opener but the mid-table visitors were unable to hang on.