Rafael Benitez’s side virtually picked itself for this Champions League last 16 tie at Anfield.
The Liverpool boss was without a host of his first-choice players, including suspended skipper Steven Gerrard.
But Harry Kewell returned after a two-month injury lay-off to partner Milan Baros up front, while Igor Biscan took over from Gerrard in centre midfield, with Luis Garcia also back from a domestic suspension.
Anthony Le Tallec and Vladimir Smicer were on the bench for this first-leg match.
Opponents Bayer Leverkusen were without key defender Jens Nowotny, who has suffered a serious cruciate knee ligament injury. His replacement was Jan-Ingwer Callsen-Bracker.
Liverpool: Dudek, Finnan, Carragher, Hyypia, Traore, Luis Garcia, Hamann, Biscan, Riise, Kewell, Baros. Subs: Carson, Smicer, Le Tallec, Nunez, Warnock, Welsh, Potter.
Bayer Leverkusen: Butt, Schneider, Callsen-Bracker, Juan, Placente, Ramelow, Freier, Ponte, Krzynowek, Berbatov, Voronin. Subs: Starke, Franca, Bierofka, Fritz, Donovan, Dum, Castro.
Referee: Kyros Vassaras (Greece)