England collapsed to their first defeat by South Africa at Twickenham for eight years as an autumn of crushing disappointment concluded with a 14-point rout.
Eddie Jones' men delivered the worst performance of a campaign consisting of a solitary victory over Japan as the 14-man Springboks, inspired by half-backs Faf de Klerk and Damian Willemse, dominated the rematch of the 2019 World Cup final.
By the end of the first half, England had spent only six seconds in the opposition 22 with their backline reduced to virtual bystanders by a vast error count and the familiar disciplinary issues.
The most brainless moment arrived shortly after the break when Jonny Hill flung De Klerk out of a ruck, prompting referee Angus Gardner to reverse a penalty, and seconds later Eben Etzebeth was over to extend the lead to 24-6.
Unlike their mesmerising comeback against New Zealand a week earlier, there were no late heroics this time even after replacement prop Thomas du Toit had been sent off in the 60th minute for a dangerous challenge on Luke Cowan-Dickie.
Henry Slade dashed over in the 72nd minute - the same stage at which the 25-25 draw with the All Blacks was made possible - but pedestrian England had rarely threatened amid a lack of ideas or tempo in attack.
In contrast, the Springboks lit up Twickenham on an otherwise drab evening by running in a sensational try through Kurt-Lee Arendse that was born out of Willemse's brilliance.
Signalling their discontent, the home fans booed when the final whistle sounded.
Unfortunately for South Africa director of rugby Rassie Erasmus, he was not present to witness a comprehensive victory as he completed a two-match ban for criticising referees during the Autumn Nations Series.
Erasmus' actions meant the half-time presentation intended to mark Wayne Barnes' 100th Test as a referee was cancelled out of fear he might receive abuse after he was targeted online having overseen the Springboks' defeat by France.
It was clear early on that Gardner had a job on his hands with multiple reset scrums and extensive back chat from both sides keeping him busy.
A high error count scarred the first half and, once De Klerk and Farrell had missed simple penalties, the Springboks scrum-half drew first blood.
Farrell missed a penalty and, when Alex Coles was penalised for the second time, South Africa used their line-out to turn the screw with Siya Kolisi held up over the line.
England were unable to escape their half and, shortly after Willemse landed a drop goal, the Springboks fly-half launched a stunning counter-attack starting on his own 22.
Accelerating into space and with help from a block on Steward, he found Willie le Roux, who presented Arendse with a one-on-one against Marcus Smith that the Bulls wing completed through his sheer pace.
Willemse was causing havoc as he broke free once more and, once England had been warned for repeated defensive infringements, De Klerk increased the lead to 14-3.
England changed their entire front row and also brought on wing Jack Nowell for the second half but it made no difference to South Africa as Willemse booted another drop goal.
Farrell replied with a penalty but Hill's moment of madness with De Klerk allowed the Springboks to attack and, with Tom Curry sent to the sin-bin for a ruck offence, Etzebeth touched down under the posts.
De Klerk converted and rifled over another three points only for Du Toit to receive his marching orders.
England were finally over in the 72nd minute, Slade darting over to end a long-range move started by Nowell, but they had nothing left in the tank against a resolute South Africa.
: Steward, Freeman, Tuilagi, Farrell, May, Smith, van Poortvliet; M. Vunipola, George, Sinckler, Itoje, J. Hill, Coles, Curry, B. Vunipola.
: Nowell for Freeman (41), Slade for Smith (60), Youngs for van Poortvliet (66), Genge for M. Vunipola (41), Cowan-Dickie for George (41), Stuart for Sinckler (41), Ribbans for Coles (45).
: le Roux, Arendse, Kriel, de Allende, Mapimpi, Willemse, de Klerk; Nche, Mbonambi, Malherbe, Etzebeth, Orie, Kolisi, Mostert, Roos.
Libbok for le Roux (60), Moodie for Arendse (77), Hendrikse for de Klerk (72), Kitshoff for Nche (45), Marx for Mbonambi (45), T. du Toit for Malherbe (57), Smith for Orie (45), van Staden for Roos (52). Sent Off: T. du Toit (60).
: Angus Gardner (Australia).