Australia have picked James O'Connor at fly-half for Saturday's opening Test against the British and Irish Lions at Suncorp Stadium with Kurtley Beale included on the bench.
The starting XV picked by coach Robbie Deans features three debutants in full-back Israel Folau, flanker Ben Mowen and inside centre Christian Lealiifano.
Folau is competing in his first season in professional rugby union, having already represented Australia at rugby league and played in the AFL.
Folau has been in stunning form at full-back for the NSW Waratahs, but has been chosen on the right wing by the Wallabies with Digby Ioane, who has recovered from knee surgery, lining up on the opposite flank.
With Beale deemed not ready to start against the Lions following his return from alcohol-related problems, Deans has opted for O'Connor at fly-half with Berrick Barnes taking the number 15 jersey.
It will be only the second time O'Connor has played a Test at 10, with the other appearance taking place alongside Will Genia against Wales in 2011.
Scrum-half Genia and the selection of Adam Ashley-Cooper were the two certainties in the Wallaby backline, with the presence of Lealiifano one of the main talking points in the build up to tonight's team announcement.
The 25-year-old playmaker also features at fly-half for the ACT Brumbies and has edged the more defensive Pat McCabe to form a centre partnership with Ashley-Cooper.
Lealiifano's inclusion indicates the Wallabies are seeking to play a more expansive game against the Lions.
Mowen, the Brumbies captain, will call the lineouts from his position at blindside flanker in a back row that also includes number eight Wycliff Palu and Michael Hooper at seven.
Hooper was the player of Australia's tour to Europe last November and profits from injuries to David Pocock and George Smith, while Scott Higginbotham is another Wallaby back row who will spend the series in the treatment room.
Captain James Horwill is partnered at lock by Kane Douglas and there is a grizzled look to the front row with Ben Alexander, Stephen Moore and Benn Robinson having amassed 180 caps.
Despite the three debutants, the Wallabies' line-up contains 519 caps but only six of the starting XV that dispatched Wales 14-12 last autumn have been retained - Barnes, Ashley-Cooper, Palu, Douglas, Alexander and Robinson.
Australia team to face the British and Irish Lions at Suncorp Stadium, Brisbane, on Saturday June 22:
B Barnes (NSW Waratahs); I Folau (NSW Waratahs), A Ashley-Cooper (NSW Waratahs), C Lealiifano (Brumbies), D Ioane (Queensland Reds); J O'Connor (Melbourne Rebels), W Genia (Queensland Reds); B Robinson (NSW Waratahs), S Moore (Brumbies), B Alexander (Brumbies), K Douglas (NSW Waratahs), J Horwill (Queensland Reds, capt), B Mowen (Brumbies), M Hooper (NSW Waratahs), W Palu (NSW Waratahs).
Replacements: S Fainga'a (Queensland Reds), J Slipper (Queensland Reds), S Kepu (NSW Waratahs), R Simmons (Queensland Reds), L Gill (Queensland Reds), N Phipps (Melbourne Rebels), P McCabe (Brumbies), K Beale (Melbourne Rebels).