Ireland internationals Ronan O'Gara, Tomas O'Leary and Donncha O'Callaghan make their first appearance this season in the Munster squad ahead of the Magners League trip to Edinburgh for the game in Murrayfield on Friday night (7.05pm).
Team Manager Shaun Payne will want his players to build on their first round win over new Italian franchise Aironi Rugby.
Payne said: "Our away form wasn't good last season, that's something we are very conscious of and looking to improve.
"This weekend is an opportunity to begin that process and so it's a massive game for us."
MUNSTER (v Edinburgh): D Hurley, F Jones, S Deasy, I Dowling, D Howlett, D Barnes, J Murphy, S Tuitupou, R O'Gara, P Warwick, D Williams, P Stringer, T O'Leary. W du Preez, M Horan, D Varley, D Fogarty, J Hayes, T Buckley, D O'Callaghan, B Holland, D Ryan, M O'Driscoll, I Nagle, A Quinlan, N Ronan, D Leamy, T O'Donnell, P O'Mahony.