Anthony Horgan and Frankie Sheahan will make their final appearance on the night Munster will be presented with the Magner's League trophy at the end of their final match of the season against The Ospreys at Thomond Park on Friday night.
It will also be the last occasion the released prop Federico Pucciariello, back-row John O'Sullivan, scrum-half Mike Prendergast and centre/wing Kieran Lewis will be involved in the Munster squad.
Captain Paul O'Connell returns from a back injury to lead the side with fellow Lions Keith Earls, David Wallace and Ronan O'Gara also in the side.
MUNSTER (v Ospreys): P Warwick; D Howlett, K Earls, L Mafi, I Dowling; R O'Gara, P Stringer; F Pucciariello, D Fogarty, T Buckley, M O'Driscoll, P O'Connell (capt), D Leamy, N Ronan, D Wallace.
Replacements: F Sheahan, Dave Ryan, D O'Callaghan, J O'Sullivan, M Prendergast, A Horgan, K Lewis.