Michael Swift, Conor McPhillips and Chris Keane have been called into the Connacht side to play Border Reivers at the Sportsground on Friday (kick off 6.30pm).
Second row Andrew Farley has failed a late fitness test this morning.
Wing Daniel Riordan has not recovered from a bug he picked up training with the Irish team.
Scrum-half Conor O'Loughlin has picked up a hip injury.
CONNACHT (v Borders):
David Slemen; Darren Yapp, John Hearty, Mark McHugh (C), Conor McPhillips; Paul Warwick, Chris Keane; Brett Wilkinson, Adrian Flavin, Stephen Knoop; David Gannon, Michael Swift; John Muldoon, Ray Ofisa, Colm Rigney.
Replacements: Conor Muldoon, Ray Hogan, Ryan Strudwick, Matt Lacey, Ted Robinson, Peter Durcan, Gavin Williams.