Championship newcomer Rory Quinlivan will partner Daithí Waters in Wexford's engine room when they take on Offaly this evening in Tullamore (throw-in 5pm).
Ben Brosnan from Bannow-Ballymitty will also make his first Leinster SFC start at wing forward in this preliminary round tie.
David Murphy captains the team from centre-back and with former All-Star Matty Forde now retired, Colm Morris has been added to a full-forward line which is completed by the fit-again Eric Bradley and Redmond Barry.
Previewing tonight's match, Wexford manager Jason Ryan said: "We have prepared well and will be approaching the game with a positive attitude. We have not had the lads until Monday of last week but they came back uninjured and focused following their club commitments.
"While we have quality in attack, Offaly also have quality defenders, but we must also show the same qualities in defence, and defend as a team.
"We'll approach this game positively as the players are at their best moving forward, attacking quickly from defence. We have prepared well and the lads are focused on the task ahead."
Wexford have not won a Leinster SFC game since overcoming Laois at the semi-final stage in June 2008. Their provincial title hopes were ended by Dublin last year, and they lost out to Kildare in 2009.
WEXFORD (SFC v Offaly): Anthony Masterson; Joey Wadding, Graeme Molloy, Brian Malone; Adrian Flynn, David Murphy (capt), Aindreas Doyle; Rory Quinlivan, Daithí Waters; Shane Roche, Ciarán Lyng, Ben Brosnan; Colm Morris, Eric Bradley, Redmond Barry.