Dublin played Kerry for the first time in the All-Ireland senior football championship back in 1892 and the counties have since clashed more than 20 times.
Derry and Westmeath have never met at senior championship level, a situation which will be rectified this weekend.
It's a contrast which adds an extra dimension to next Saturday's Bank of Ireland quarter-finals at Croke Park which is expected to attract a full house.
The line-up is as follows:
Derry v Westmeath, 2.00 (Referee: M Curley, Galway)
Dublin v Kerry, 3.45 (Referee: P McEnaney, Monaghan)
Always one of the great rivalries in Gaelic football, Kerry and Dublin go head to head, with the winners set to play Derry or Westmeath in the semi-final on August 29.
This will be the first championship meeting between Dublin and Kerry since 2001, when Kerry won in a replay.
Dublin have yet to concede a goal in this year's championship, while they have scored five. Kerry have scored four goals and conceded three.
Kerry will be appearing in the All-Ireland quarter-final for the fourth successive year and is the only county to reach the last eight every season since the new championship system was introduced in 2001.
They have yet to be beaten in the quarter-finals. Dublin reached the quarter-finals in 2001 and 2002.
Derry and Westmeath clash for the first time in the senior championship. Both counties reached the 2001 quarter-finals, where Derry beat Tyrone (1-9 to 0-7) while Westmeath drew with Meath (3-9 to 2-12) prior to losing the replay (2-10 to 0-11).
Westmeath conceded just one goal in their history-making march to their first Leinster title this year but, interestingly, they scored just two goals – both against Wexford – in five games.
Derry lost heavily to Tyrone in the preliminary round of the Ulster championship, but were a different side in the All-Ireland qualifiers, beating Wicklow, Cavan, Wexford and Limerick.
Fermanagh are in the All-Ireland semi-final for the first time in their history. The last county to reach the last four for the first time was Longford in 1968.
Fermanagh will play Mayo in the semi-final on Sunday week, August 22.
Mayo are back in the All-Ireland semi-final for the first time since 1999. It will be the fifth time that manager John Maughan has taken a side to the semi-finals.
He was in charge of Clare when they reached the 1992 semi-final and led Mayo to semi-finals in 1996, 1997 and 1999.