Wexford make four changes from the side that was hammered by Kilkenny in the Leinster Hurling Final for Sunday's All-Ireland Hurling Quarter-Final against Limerick at Croke Park.
In addition, three Championship debuts are handed out by manager Tony Dempsey.
Both corner-backs are replaced - Rory Mallon replaces Colm Kehoe, while Sean Flood drops out in place of David O'Connor.
Ryan Quigley's injury sees Nicky Lambert slotting in at centre-field, with Trevor Kelly in for Barry Goff at centre-forward.
One other item of note sees a vacancy left at right half-forward, as Declan Ruth is battling to shrug off a hamstring injury.
Wexford - 1 Damien Fitzhenry; 2 Rory Mallon, 3 Darragh Ryan, 4 David O'Connor; 5 AN Other, 6 Liam Dunne, 7 Larry O'Gorman; 8 Adrian Fenlon, 9 Nicky Lambert; 10 Darren Stamp, 11 Trevor Kelly, 12 Paul Codd; 13 Mitch Jordan, 14 Larry Murphy, 15 Rory McCarthy