Murphy, who retired after the 2013 championship, was persuaded to come back to the set-up by manager Jimmy Barry-Murphy and is named at left corner-back.
Aidan Ryan, who was full-back in the Allianz HL Division 1 final loss to the Déise at the same venue five weeks ago, loses out as Stephen McDonnell moves to full-back.
In the half-back line, Damien Cahalane comes in for Lorcán McLoughlin, who is ruled out through a shoulder injury.
Left half-back Cormac Murphy is selected for his championship debut.
Séamus Harnedy had been a worry with a hamstring problem but he has been passed fit to start at centre-forward.
That means Luke O’Farrell for Robert O’Shea is the only other change, with Conor Lehane moving from full-forward to number 10 to accommodate his Midleton clubmate.
In the curtain-raiser at Thurles, Cork face Waterford in the Munster intermediate championship with a 2pm throw-in and, with Cork having won the All-Ireland last year, manager Ronan Dwane has to assemble a brand-new panel.
Captain Kevin Kavanagh of Carrigaline, who is at right half-back, and left half-forward Michael Collins (Ballinhassig), were both U21s last year.
Collins’ clubmate Fintan O’Leary was previously a part of the senior panel.
Full-back Brendan Rogers of Slaughtneil is the only debutant on the Derry side to face Down in Celtic Park at 2pm. Niall Holly, who featured at full-back during the league, makes his first championship start, partnering Fergal Doherty at midfield.
VISIT OUR SPORTS HOME PAGE HERE
A Nash (Kanturk); S O’Neill (Bishopstown), S McDonnell (Glen Rovers), B Murphy (Bride Rovers); D Cahalane (St Finbarr’s), M Ellis (Millstreet), C Murphy (Mallow); D Kearney (Sarsfields), A Walsh (Kanturk); C Lehane (Midleton), S Harnedy (St Ita’s), B Cooper (Youghal); A Cadogan (Douglas), L O’Farrell (Midleton), P Horgan (Glen Rovers).
P Collins (Ballinhassig), W Kearney (Sarsfields), K Burke (Midleton), A Ryan (Midleton), P Cronin (Bishopstown), B Lawton (Castlemartyr), R O’Shea (Carrigaline), D McCarthy (Ballymartle), S Moylan (Douglas), P O’Sullivan (Cloyne), J Coughlan (Newtownshandrum).
P Buckley (Mallow); B Ó Tuama (Castlemartyr), E Finn (Ballinhassig), G Murphy (Newcestown); K Kavanagh (Carrigaline), D O’Donovan (Ballinhassig); T Lawrence (Brian Dillons); D O’Flynn (Charleville), S McCarthy (Ballinhassig); W Leahy (Aghada). A Cagney (Charleville), M Collins (Ballinhassig); N McNamara (Kilworth), F O’Leary (Ballinhassig), T Murphy (Carrigaline).
S O’Sullivan (Meelin), K Lane (Kilworth), P Butler (Argideen Rangers), M Brennan (Fermoy), K Sheehan (Kilbrin), J Sheehan (Argideen Rangers), J Morrissey (Ballyhea), A Sheehan (Mallow), P Herlihy (Mallow).
D McDermott (Banagher); M Warnock (Swatragh), C Quinn (Swatragh), S McCullagh (Banagher); A Rafferty (Eoghan Rua), C McSorley (Ballinascreen), K Hinphey (Kevin Lynch); S McGuigan (Ballinascreen), B Quigley (Na Magha); P McCloskey (Kevin Lynch), P Cleary (Ballinascreen), P Henry (Lavey); A Kelly (Ballinascreen), R Convery (Swatragh), A Grant (Na Magha).
T Mallon (Loup); O Duffy (Foreglen), B Rogers (Slaughtneil), D McBride (Ballinascreen); K Johnston (Dungiven), C McKaigue (Slaughtneil), C McFaul (Glen); N Holly (Eoghan Rua), F Doherty (Bellaghy); SL McGoldrick (Eoghan Rua), M Lynch (Banagher), E Lynn (Greenlough); B Heron (Ballinascreen), E Bradley (Glenullin), D Heavron (Magherafelt).
E McNicholl (Glenullin), L McGoldrick (Eoghan Rua), A McAlynn (Loup), C McAtamney (Swatragh), T O’Brien (Loup), N McNicholl (Glenullin), C Murphy (Dungiven), J Kielt (Kilrea), C O’Boyle (Lavey), D McKinless (Ballinderry), N Loughlin (Greenlough), B Óg McGilligan (Banagher), S Brady (Ballymaguigan).