Wing-back Aidan O’Reilly, midfielder Micheál Ó Laoire, wing-forward Liam Shorten and full-forward Seanie Cahalane will all make their bows at this level.
O’Neill is selected at right corner-forward in what will be his first game for Cork since the league tie with Galway last March and is joined in that line of attack by Kevin O’Sullivan, who features for Cork for the first time since March 2009.
Graham Canty is a notable inclusion at centre-back as he starts a competitive game outside of championship for Cork for the first time since April 2010, having been hampered by injury setbacks in recent seasons.
Limerick manager Maurice Horan has also handed out several debuts for their McGrath Cup tie with UCC in Rathkeale on Sunday. Wing-back Eoin Barry, the half-forward line of Darragh Treacy, Mike Quilligan and Phillip Maloney, and full-forward Dinny Ahern are the newcomers for the Shannonsiders.
CORK (SF v Clare): K O’Halloran (Bishopstown); E Cotter (Douglas), R Carey (Clyda Rovers), K Harrington (Bantry Blues); C O’Driscoll (Ilen Rovers), G Canty (Bantry Blues), A O’Reilly (Nemo Rangers); J Fitzpatrick (Carbery Rangers), M Ó’Laoire (Naomh Aban); F Lynch (Valley Rovers), F Goold (Macroom), L Shorten (Ballingeary); C O’Neill (Ballyclough), S Cahalane (Castlehaven), K O’Sullivan (Ilen Rovers).
LIMERICK (SF v UCC): B Scanlon (Gerald Griffins); M McCormick (Mungret), J McCarthy (St Kieran’s), L O’Dwyer (Pallasgreen); E Barry (Drom-Broadford), J Riordan (Fr Casey’s), P Ranahan (Ballysteen); E Joy (Fr Casey’s), P Kinnerk (Monaleen); D Treacy (St Kieran’s), M Quilligan (Newcastlewest), P Maloney (Glin); G Collins (Monaleen), D Ahern (Kilteely-Dromkeen), D Kelly (Fr Casey’s).
TYRONE (SF v Antrim): J Devine; A McCrory, C Clarke, D Carlin; R McNamee, J McMahon, S McNulty; A Cassidy, C Cavanagh; P Harte, P Hughes, R McNabb; C Gervin, N McKenna, R O’Neill.