Without talismanic forward Declan Browne, who was ruled out with an ankle injury, Rovers played second fiddle to the 2004 county champions in the second half.
Loughmore-Castleiney, who last contested a county SF final in 2005, restricted toothless Rovers to a late goal in the second half while Cian Hennessy scored a crucial 40th-minute goal for the winners.
Scorers for Loughmore-Castleiney: C Hennessy 1-1, N McGrath 0-2, J Egan 0-2 (1f), T King, D Kennedy, E Sweeney & L McGrath 0-1 each.
Scorers for Moyle Rovers: P Acheson 1-0, P Shanahan 0-2 (1f), D Nolan, S Carey & D Foley 0-1 each.
LOUGHMORE-CASTLEINEY: D McGrath; T Long, E Connolly, W Eviston; T King, C McGrath, A McGrath; J Scully, D Kennedy; J Egan, E Sweeney, M Webster; L McGrath, N McGrath, C Hennessy.
Sub: L Treacy for Scully (41).
MOYLE ROVERS: K Kenrick; D Conway, R Power R Dsemond; S Keating, D O’Dwyer, D Nolan; J Williams, P Acheson; S Carey, B Mulvihill, M Dunne; D Foley, P Foley, P Shanahan.
Subs: J Shanahan for Williams (43), J Lonergan for D Foley (46), L Boland for P Shanahan (58), A Kelly for Keating (59).
Referee: P Russell (Emly).