Midfielder Cian Mullins has recovered from a hamstring injury to take his place alongside Sean Murray with Mark Coughlan making way.
In attack David Quinn (Lucan Sarsfields) starts at right half-forward and Ted Furman will play at centre-forward with David Quinn (Na Fianna) and Gavan McIntyre the two players to make way.
Positional changes see Daragh Nelson move to left corner-back with team captain Johnny Cooper going to right half-back, Ciaran Dorney moving out to right half-forward and Dean Rock now starting at full-forward.
Tipperary have made just the one change for their last four tie against Donegal, with manager John Evans drafting Munster final scoring hero Shane Egan into his starting line-up at full-forward with Brian O’Meara dropping to the bench.
Aldo Matassa, who was drafted into the team for the Munster final before throw-in in place of the injured Gavin Ryan, retains his place at left half-forward.
DUBLIN (U21FC v Roscommon): V Whelan; E Culligan, R O’Carroll, D Nelson; J Cooper, J McCarthy, N Devereux; C Mullins, S Murray; D Quinn (Lucan), T Furman, G Sweeney; B O’Rourke, D Rock, C Dorney.
TIPPERARY (U21FC v Donegal): K Kenrick; P Kiely, C McDonald, D Lynch; P O’Dwyer, J Coghlan, D Dwyer; A Maloney, P Acheson; S Carey, B O’Brien, A Matassa; C Sweeney, S. Egan, M O’Dwyer.