Conor O'Shea makes four changes for Italy's visit to Twickenham

Italy have made four changes to the team thrashed by Ireland for Sunday's RBS 6 Nations match with holders England at Twickenham.

Head coach Conor O'Shea's side were thumped 63-10 by Ireland in Rome last time out, coming on the back of a 33-7 home loss to Wales on the tournament's opening weekend.