With Brook under intense pressure from the champion’s latest assault, already appearing tired and his right eye cut and swollen, Ingle ended the fight to conclude a resilient performance.
The challenger was taken to hospital with a broken eye socket before being released in the early hours of Sunday morning. He is to be operated on in the coming week, before preparing for an eventual return to the ring at light-middleweight.
“I came back after the second round and said ‘I can’t see out of the right eye, Dominic’,” Brook, 30, said afterwards.
“I was talking to him, and he knows me, he saw me growing up as a kid.
“He’s like a father figure. It was the right decision and I can fight another day. I was getting caught, and getting caught. It could have ended up seriously bad.
“As much as the loss has been gutting and upsetting, I’m excited and happy the fans have seen a great battle against a great fighter, a throwback fighter. I’m looking forward to getting straight back in the top boys. I’ve had a taste of this magnitude of fight and I want this again
Brook had been the significant underdog having stepped up from welterweight against one of the world’s leading and most destructive fighters.
Few observers believed him capable of winning, but his promoter Eddie Hearn regardless maintained fighting Golovkin was the right thing to do.
“Peter Nelson (executive president of American television network HBO) has already come up to me and said: ‘We need to talk about Kell Brook’,” said Hearn.
“That was part of the plan: to broaden the brand. So actually, it was a very smart move.”
Brook’s domestic rival Amir Khan last fought at 155lbs when losing to Mexico’s Saul Alvarez in May but is expected to return at welterweight in 2017.
The weight Brook gained to challenge Golovkin, combined with his previous, intense struggles to make the 147lb limit means he is likely incapable of returning there. Hearn, however, again spoke of his desire to match the two together.
“As a promoter there is nothing better in a build-up than two fighters who don’t particularly like each other,” the 37-year-old said.
“But for now it’s about getting that eye socket tidied up, having some rest and he’ll probably be returning in the spring, summer next year.”
The 34-year-old Golovkin’s performance again demonstrated why he is considered one of the greatest middleweights in history and why he is so widely feared.
His possession of the IBF, WBC and WBA titles - the WBA refused to sanction theirs for Saturday’s fight - has made WBO champion Billy Joe Saunders his next target.
Victory over Saunders would unify the division’s four world titles, and asked who he next wanted to fight, the Kazakh said: “First of all Billy Joe Saunders, and then ‘Canelo’ (Saul Alvarez). Now I want a unification fight.
His promoter Tom Loeffler said that America’s Danny Jacobs is another potential opponent, and added: “Maybe (Brook’s performance) will give (other opponents the) courage to actually sign a contract.”