Lopez thumps Roddick
The three-time runner-up had looked impressive in his first two matches but was outplayed in every department by Lopez, who hit 57 winners and made only seven unforced errors in a 7-6 (7/2) 7-6 (7/2) 6-4 win.
Greg Rusedski, Andy Murray and Roger Federer, who did it twice, are the only other players to have denied Roddick a set at the All England Club, Murray the last to do it in 2006.