The HSE has apologised after a number of vials of the Covid-19 vaccine had to be disposed of after they were incorrectly stored.
Around 130 Pfizer-BioNTech doses had to be discarded.
The 22 vials were delivered to a nursing home in its Midlands Louth Meath Community Healthcare group.
The vials were incorrectly stored and the cold chain was not in place meaning the doses could not be used.
"It is disappointing for all concerned, residents and staff. We are sorry that this incident has taken place," the HSE said in a statement this evening.
The 49 residents and staff at the nursing home were successfully vaccinated.
The HSE has said it is very conscious that this news is upsetting for families, residents and staff members.
A range of supports are being offered to all concerned and the breach has been reported.
The HSE said all necessary processes will be followed and the Community Healthcare Organisation will now work with national colleagues to undertake the remaining vaccinations at the LTRC facility as soon as possible.