Drug appears to slow down progression of Alzheimer’s

Drugs that could be the “first” to slow the progression of Alzheimer’s disease have been unveiled.

Researchers revealed the the promising results of studies into the use of solanezumab and aducanumab.

Results suggest that if given to patients early enough, the antibody therapies will be able to slow cognitive decline.

Interim results from a safety study of Biogen’s aducanumab, in people with very early stage Alzheimer’s disease, show that the drug reduces the amount of the amyloid plaques in the brain, with an increasing effect as the dose increases.

The discovery was announced at the Alzheimer’s Association international conference in Washington DC, which saw studies of three alternative antibody therapies presented.

More than a quarter of people on the higher doses experienced headaches and a third to a half experienced abnormalities on a brain scan.

Long-term analysis of pharmaceutical company Eli Lilly’s solanezumab reports that people with mild Alzheimer’s disease, who have taken the drug for three-and- a-half years, show some benefits in cognition compared to those who have only taken it for two years.

Dr Doug Brown, head of research at the Alzheimer’s Society in Britain said: “Today’s findings strongly suggest that targeting people in the earliest stages of Alzheimer’s disease with these antibody treatments is the best way to slow or stop Alzheimer’s disease.

“These drugs are able to reduce the sticky plaques of amyloid that build up in the brain, and now we have seen the first hints that doing this early enough may slow disease progression.

“After a decade of no new therapies for dementia, today’s news is an exciting step forward.

“We will have to wait for the ongoing trials to finish to know the full risks and benefits of these drugs. If they are positive, these drugs will be the first identified to directly interfere with the disease process and slow the progression of Alzheimer’s.”

Referring to aducanumab, he warned that although the results leaned towards a treatment that could slow the disease, the drug was not without side-effects.

In relation to solanezumab, Dr Brown added: “It’s good news that some people have been receiving the antibody for over three years and it appears to be having beneficial effects.

“The current trial has finished recruiting participants, so in just 18 months we may get an exciting first look at the final results.”

A woman diagnosed with early onset Alzheimer’s aged 58, has said she is “quietly optimistic” about a potential breakthrough drug.

Wendy Mitchell, now 59, said she was “devastated” to be diagnosed with the disease exactly a year ago and has noticed her memory deteriorate further over the period. The mother-of-two from York is taking donepezil, which can temporarily alleviate symptoms such as anxiety and memory and concentration problems, but only on a short-term basis.

She said that, while the announcement on the drug solanezumab may not necessarily help her, it is good news nonetheless.

“We haven’t had any breakthroughs for 19 years,” she said. “We’ve been waiting a very long time for a new treatment or development. I’m quietly optimistic but not naive enough to think it will necessarily benefit me.”