Gardaí and the Central Bank, which last year bought the eight-storey shell in the Dublin docklands, have launched separate probes into the vandalism, which happened overnight.
Several messages — including “Zionist engineered global financial holocaust”, “Jewish supremacist destruction of indigenous Europeans”, “Zionist global financial terrorism” and “Jewish financial terrorism” — have been scrawled in large red letters in the skeleton-like building.
The Central Bank said the graffiti over several floors of the cement shell on North Wall Quay will be removed as soon as possible.
“There are security arrangements in place at the site,” it said.
“We will now investigate how these failed to prevent this break-in and damage, and how they can be improved to mitigate this happening again.”
A Garda spokesman confirmed officers at Store St are investigating.
The sealed-off site was once valued at €250m and was earmarked as the new headquarters for the toxic lender Anglo until its collapse. It was on the market with Nama for €8m to €10m when sold to the Central Bank over a year ago.
The site was originally bought by developer Liam Carroll, one of the biggest and first names to go bust in the recession.
His Zoe Developments group entered into liquidation in 2009 with debts of €1.3bn and Judge Peter Kelly would later remark how the shell was a “fitting tombstone to the Celtic Tiger”.