Most every NFL player knows that a quick way to get ushered to the sidelines — or beyond — is fighting.

Quarterback Jimmy Garoppolo did not miss a beat as he stepped in for the suspended Tom Brady in his first NFL start and led the New England Patriots to a 23-21 win over the Arizona Cardinals.

Andrew Luck enjoyed a landmark day as the Indianapolis Colts beat the Washington Redskins 49-27 on Sunday.

An embattled NFL, reeling from off-field brutality issues, received more bad news with numerous injuries to key players in the second week of an already tumultuous campaign.