For Ireland to reach its economic development potential over the next 20 years, Irish policymakers need to undergo a change of mindset. Priority should be given to developing critical masses of internationally competitive indigenous enterprises. To do this involves seeing economic development as a bottom-up organic process as opposed to the existing over-centralised view. It requires that we design fit-for-purpose city regions, towns and rural places and that control and responsibility for enterprise development be decentralised to elected authorities in these places with tax raising powers.