A spate of disappointments in the pharmaceutical and biotech sectors triggered a broad sell-off on Wall Street today, sending the Dow Jones industrials, Nasdaq composite and Standard & Poor’s 500 indexes to their lowest closes of the year.

The FTSE 100 Index is nearing a four-month low at mid-morning, falling 46.8 points to 5026.5.

The FTSE 100 Index is being pushed down towards the key 5,000 mark again, falling 36.6 points to 5036.7 after an hour's trading.

Sellers resurfaced on Wall Street late today, unloading stocks following the previous sessions’ buying binge.

Wall Street’s hope for a rebound fizzled today, with investors drawn to the stock market’s relatively cheap prices but hesitant amid continuing questions about accounting practices. Stocks fluctuated throughout the session before closing modestly lower.

New questions about accounting practices at Tyco and Enron provoked a broad selloff on Wall Street today as investors grew more doubtful about the honesty of corporate bookkeeping in general.

Divergent signals on the state of US business left investors cautious and prices mixed on Wall Street today.

Technology selling has put pressure on US stocks, resulting in a mixed market despite strong gains in the financial and energy sectors.

A strong jump in November housing construction propelled stock prices to sharp gains on Wall Street today and fuelled investors’ hopes that the US economy is improving.

US investors, attracted to Wall Street by cheaper prices, today set aside nagging pessimism about the economy and indulged in late-session buying.

Profit warnings from Ciena and Lucent Technologies, and news of more layoffs and deteriorating retail sales, unnerved Wall Street today and prompted heavy selling.

Strength in the technology sector has sent US stocks soaring.

A jetliner crash in New York today gave Wall Street a sharp reminder that more terrorist attacks are possible and prompted shaken investors to refrain from any major moves.

Boosted by some healthier-than-expected earnings reports, Wall Street surged higher today, carrying the Dow Jones industrials and other market indexes to levels last seen before the September 11 terrorist attacks.

Wall Street found some stability today, leaving stocks barely changed following the sell-off last week that sent the major indexes to some of their lowest levels of the year.

Stocks drifted lower in New York today, despite a better-than-expected Commerce Department report showing that the weak US economy has not kept consumers from spending.

Concerns about weak company profits ruled Wall Street again yesterday, foiling the market's attempts to rally on comments from Oracle.