The question was asked by a female member of the audience who said she herself was a Muslim.
"There are 3.3m Muslims in the United States and I am one of them.
"You've mentioned working with Muslim nations, but with Islamophobia on the rise, how will you help people like me deal with the consequences of being labelled a 'threat to the country' after the election is over?"
The Republican candidate Mr Trump was quick to respond to the question.
"One thing we have to do is we have to make sure that because there is a problem, whether we like it or not — and we could be very politically correct, but whether we like it or not, there is a problem and we have to be sure that Muslims come in and report when they see something going on.
"When they see hatred going on, they have to report it."
"In San Bernardino, many people saw the bombs all over the apartment of the two people that killed 14 and wounded many, many people. Horribly wounded. Never be the same.
"Muslims have to report the problems when they see them. And you know, there's always a reason for everything. If they don't do that, it's a very difficult situation for our country because you look at Orlando.
"And you look at San Bernardino and the World Trade Center. Look at Paris.
"The horrible, these are radical islamic terrorists. And she won't even mention the word and nor will President Obama."
Mr Trumps comments gave rise to the trending #MuslimsReportStuff in which members of the Muslim community did just that, reported stuff.
Hi, I'm Muslim & want 2 report a man in St. Louis butchering English by stringing adjectives & passing them as sentences #MuslimsReportStuff— Muna Ali (@munamali) October 10, 2016
I think my sister drank orange juice straight out of the carton, will continue to investigate #MuslimsReportStuff— b (@broundsugar) October 10, 2016
I am bullied and harassed by Trump supporters EVERY DAY. #MuslimsReportStuff— amelia noor-oshiro (@ANoorOshiro) October 10, 2016
I saw armed jihadists curse the US gov & swear they'd fight to the death but turned out they were white supremacists. #MuslimsReportStuff— Hend Amry (@LibyaLiberty) October 10, 2016