Henry Shefflin is set to miss his first Championship match in 15 years - Kilkenny's upcoming Leinster SHC quarter-final against Offaly - due to a stress fracture in his left foot.
It is the same foot that he underwent surgery on in December which forced him to sit out the Cats' successful Allianz League campaign.
In his latest injury setback, Shefflin damaged his metatarsal during light training and an MRI scan on Monday revealed a Lisfranc injury - a foot injury in which one, or all, of the metatarsal bones are displaced from the tarsus.
The 34-year-old was itching to return to action and extend his incredible record of starting 62 successive Championship matches with the Kilkenny senior hurlers.
He had been hoping to have a short run-out with his club Ballyhale Shamrocks against Clara tomorrow night, but is now resigned to some further time on the sidelines.
Speaking at the launch of the Lucozade Sport Club Crusade, he said: "I'm not going to lie and say I wouldn't love to play in it (the Offaly match on June 9). Of course I would.
"But I would have said it this time last year, there's no point in playing unless you're right. And I'm not right so there's no point, that's basically it.
"That'll be it, it will be over and you move on with the next match. So it doesn't really matter to me that much (the ending of his record run of Championship starts)."
Shefflin is well used to fighting his way back to full fitness after surgery.
The 2012 Hurler of the Year has come back from two cruciate knee ligament injuries in recent seasons and battled back from a serious shoulder problem to boot. He also spent time in hospital with pneumonia at the start of the year.
The air-cast 'space boot', used during his recovery from foot surgery last winter, is now back on as he sets out on another few weeks of rest before getting back on the pitch.
"It's the early stages of a stress fracture which is good, there's no crack or anything. It's just resting up for a few weeks and, hopefully, then bang on again. That's the plan.
"With the original injury I had, my foot wasn't on the ground for three or four months so it means your foot isn't used to training and it just reacts.
"I was back doing a bit of training for the last couple of weeks since I got the pins out.
"Over the weekend, it reacted a small bit. I was in to see the surgeon On Monday and that's why I'm back in the boot."
With some uncertainty at present over Shefflin's likely return, the nine-time All-Ireland winner is also doubtful for a potential Leinster semi-final on June 23 with the provincial decider scheduled for July 7.
He added: "I'm due back in to the surgeon in about two or three weeks' time. I'll see what the prognosis is then, how things are going. It's just rest — same as anyone with a stress fracture.
"It's on the metatarsal. A lot of people thought it was my ankle but it wasn't, it was a Lisfranc injury which is basically my midfoot.
"It's uncommon enough but the stress fracture is on the top of one of my metatarsals, going into my toes.
"It's going to be very much 'wait and see' and once I get back I have to be careful again and just build it up right.
"Match fitness is going to be an issue because that's what you need to build up. You can do as much training and running up and down the sideline as you can but match fitness is an issue.
"But again, maybe you could say you'll be fresh but it's very much a wait and see kind of job at this stage."