Snakes’ long bodies linked to one gene

Snakes owe their long, slithery bodies to a single gene, research has shown.

The Oct4 gene regulates stem cells and affects the growth of the middle part, or trunk, of a vertebrate’s body.

In snakes, a quirk of reptilian evolution has resulted in Oct4 remaining “switched on” for longer than usual during embryonic development.

Dr Rita Aires, from the Instituto Gulbenkian de Ciencia (IGC) in Lisbon, said: “The formation of different body regions works as a strong-arm contest of genes. Genes involved in trunk formation need to start ceasing activity so that genes involved in tail formation can start working.

“In the case of snakes, we observed that the Oct4 gene is kept active during a longer period of embryonic development, which explains why snakes have such a long trunk and a very short tail.”

The discovery was made while studying mice that had unusually long trunks.

Understanding the role of Oct4 in keeping the snake’s body long may shed new light on spinal cord regeneration, the scientists said.

Study leader Dr Moises Mallo, said: “

We will investigate if we can use the gene to help in cases of spinal injury.”


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