Bill Bailey is stepping down as a team captain on 'Never Mind The Buzzcocks' after 11 series on the TV quiz show.
The comedian's place on the BBC2 show will be filled by celebrity guest captains.
They include music producer Mark Ronson in the first episode of the new series, followed by Frank Skinner, Dermot O'Leary, Jack Dee, Johnny Vegas and Bob Mortimer.
Simon Amstell returns for his third series as host of the satirical pop quiz next month.
Bailey, 44, who had been on the show since 2002, has stepped down because of other work commitments.
The show's producer, talkbackThames, said: "After 11 series selflessly, heroically and hilariously captaining one side on Never Mind The Buzzcocks, other commitments have sadly led to Bill Bailey being unable to take part in the forthcoming series of the hit comedy pop quiz."
'Never Mind The Buzzcocks' launched in 1996 and is one of BBC2's longest-running shows.
Former stand-up comedian Amstell took over as host from Mark Lamarr in 2006.
Bailey was replaced by Noel Fielding as guest team captain for three episodes in the last series.