Widespread HPV vaccination programmes ‘could eliminate cervical cancer’

Widespread HPV vaccination programmes ‘could eliminate cervical cancer’

Cervical cancer could be eliminated by widespread HPV vaccination programmes, according to scientists who reviewed studies of 60 million people in affluent countries.

The treatment was linked to a huge reduction in the two types of HPV – 16 and 18 – which cause 70% of cervical cancers, research found.

Rates of both types of HPV in high-income countries, among girls aged 13 to 19, plummeted by up to 83% following five to eight years of vaccination, while a reduction of 66% was found in women aged 20 to 24.

A significant decrease was also seen in anogenital wart diagnoses and precancerous cervical lesions which can develop into cancer.

(Optimising HPV vaccination programmes) could make it a hallmark investment of cancer prevention in the 21st century

Professor Marc Brisson, a member of the research team, said: “Because of our finding, we believe the World Health Organisation (WHO) call for action to eliminate cervical cancer may be possible in many countries if sufficient vaccination coverage can be achieved.”

The researchers, whose work was published in The Lancet journal, analysed 65 studies from 14 high-income countries.

Declines in the HPV “endpoints” were found eight to nine years after girls-only vaccination.

The findings support the recently revised WHO position on vaccinating multiple age groups, rather than a single cohort, when introducing the vaccine.

The NHS currently offers the first dose of the HPV vaccine to girls aged 12 and 13, with a second six to 12 months later.

Earlier analysis of studies for four years post-vaccination has also shown substantial decreases in HPV 16 and 18.

The studies looked at for the new research compared levels of one or more HPV endpoints across pre and post-vaccination periods.

An overall 54% reduction was also found in three other types of HPV – 31, 33 and 45 – in girls aged 13 to 19.

Meanwhile, a decrease in anogenital warts of 67% was seen in girls aged 15 to 19, 54% in women aged 20 to 24 and 31% in those aged 25 to 29.

Reductions of 48% were found in boys aged 15 to 19 and 32% in men aged 20 to 24 years.

Five to nine years after vaccination, precancerous cervical lesions decreased by 51% in screened girls aged 15 to 19 and by 31% in women aged 20 to 24.

Co-researcher Melanie Drolet, from the CHU de Quebec-Laval University Research Centre, said: “Our results provide strong evidence that HPV vaccination works to prevent cervical cancer in real-world settings, as both HPV infections that cause most cervical cancers and precancerous cervical lesions are decreasing.”

She said the research “reinforces WHO’s recently revised position on HPV vaccination”.

Prof Brisson, from Laval University, Canada, said “it will be crucial” now to continue to monitor the impacts of vaccination programmes.

But the findings should not be extrapolated to low and middle-income countries where the burden of disease was far greater, the team warned.

Their research also found there were greater and faster impacts, and herd effects, in countries with both multi-cohort vaccination and high vaccination coverage.

Anogenital wart diagnoses declined by 88% among girls and 86% in boys aged 15-19 in these countries, compared with 44% and 1% respectively in countries with single-cohort or low coverage.

Likewise, after five to eight years of vaccination, precancerous cervical lesions decreased by 57% in girls aged 15 to 19, while there was no decrease in countries with single-cohort vaccination or low routine coverage.

Professor Silvia de Sanjose, from the PATH organisation in the USA, said optimising HPV vaccination programmes could make it “a hallmark investment of cancer prevention in the 21st century”.

- Press Association

More on this topic

Government bid to end anti-vaccination mythsGovernment bid to end anti-vaccination myths

Make vaccinations mandatory: Let’s face down flawed thinkingMake vaccinations mandatory: Let’s face down flawed thinking

Irish trust in vaccines below global average, report findsIrish trust in vaccines below global average, report finds

Jessica Biel explains stance on vaccinations after opposing California measureJessica Biel explains stance on vaccinations after opposing California measure

More in this Section

May urges successor to seek Brexit agreement as fears of no-deal growMay urges successor to seek Brexit agreement as fears of no-deal grow

May warns political discourse going ‘towards much darker place’ in final speech as British PMMay warns political discourse going ‘towards much darker place’ in final speech as British PM

Man convicted of murder of British teenager in GoaMan convicted of murder of British teenager in Goa

Mexican drug lord El Chapo sentenced to life in US prisonMexican drug lord El Chapo sentenced to life in US prison


Lifestyle

Christy Collard and Robin O’Donovan are parents to six children, but sustainability is still a cornerstone of their busy lives in west Cork.The family that composts together stays together

Ron Howard was happy to let the spirit of Luciano Pavarotti shine through in his documentary on the great tenor, writes Laura Harding.Hitting the right note with new Luciano Pavarotti documentary

Prevention is so much better than cure, says Fiann Ó Nualláin, who offers gardeners timely advice on guarding face and body against those potentially damaging ultra-violet rays this season and beyond.Gardening: Be skincare-savvy for summer

It's never been more important to choose flowers and trees according to their environmental needs, says Peter DowdallIn these times of climate change, choose plants to weather all conditions

More From The Irish Examiner