President Donald Trump and Russian counterpart Vladimir Putin have signalled the prospect of increased co-operation in Syria after what the White House described as a "very good" phone discussion that included a focus on setting up safe zones in the war-torn nation.
The White House said the leaders also agreed to try to set up their first in-person meeting in July, on the sidelines of an international summit in Germany.
The phone call marked the first time Mr Trump and Mr Putin have spoken since the US launched missiles against an air base in Syria, an attack that outraged Russia - one of the Syrian government's strongest backers.
The military action sparked new tension between Washington and Moscow, with top US officials sharply condemning Mr Putin's continued support for embattled Syrian leader Bashar Assad.
But the leaders appear to again be edging towards closer co-operation following Tuesday's call.
The Kremlin said Mr Trump and Mr Putin agreed to bolster diplomatic efforts to resolve the Syrian civil war, which has left hundreds of thousands dead and millions more displaced.
The White House announced it would send a top State Department official to Russian-led talks on Syria that begin on Wednesday in Kazakhstan.
"President Trump and President Putin agreed that the suffering in Syria has gone on for far too long and that all parties must do all they can to end the violence," the White House said.
"The conversation was a very good one, and included the discussion of safe, or de-escalation, zones to achieve lasting peace for humanitarian and many other reasons."
The Kremlin described the call as "business-like" and "constructive". It made no mention of safe zones.
Despite having previously warned against US intervention in Syria, Mr Trump ordered the strikes against Syrian government targets in early April after accusing the regime of using chemical weapons in a deadly attack on civilians.
Russia said the US strikes violated international law.
Some of Mr Trump's top advisers, including Secretary of State Rex Tillerson and United Nations Ambassador Nikki Haley, levelled blistering criticism on Russia and Mr Putin following the chemical weapons attack.
Yet Mr Trump has continued to hold out the prospect of a stronger relationship with Russia, which was a cornerstone of his foreign policy platform as a presidential candidate.
He took to Twitter days after the Syria strikes to say that "things will work out fine" between the US and Russia and "everyone will come to their senses".
The shifts in the Trump administration's posture came amid a steady swirl of controversy surrounding possible ties between the president's associates and Russia during last year's election. The FBI and congressional committees are investigating whether Mr Trump's campaign co-ordinated with Russia as it meddled in the election.
Hillary Clinton, Mr Trump's defeated Democratic opponent, said during an appearance on Tuesday that she was "on the way to winning" the election until "intervening events" in the campaign's final days, including WikiLeaks' release of hacked emails from one of her top advisers. US intelligence agencies have assessed that Russia was behind the hacking.
Mr Putin, who met earlier on Tuesday with German Chancellor Angela Merkel, denied that Moscow ever interferes in other countries' elections. He said accusations of Russian meddling aimed at helping Mr Trump in his race against Mrs Clinton were "simply rumours" being used as part of a political fight in Washington.
Mr Trump has vigorously denied any nefarious ties to Moscow, calling the Russian investigations a "hoax".