Three people have been injured, two of them critically, in a shooting on a high-speed French train travelling from Amsterdam to Paris.
Two of the victims are in a critical condition, according to a statement from the office of President Francois Hollande.
A spokesman for France’s interior ministry said a suspect is in custody and the train has been evacuated.
The motivation for the attack is unknown.
Christophe Piednoel, a spokesman for national railway operator SNCF, said the suspect was armed with a Kalashnikov rifle and a knife.
He said two American passengers subdued the gunman and one is in hospital with serious wounds.
Mr Cazeneuve said the American passengers “were particularly courageous and showed great bravery in very difficult circumstances” and that “without their sangfroid we could have been confronted with a terrible drama”.
A second person was also seriously wounded in the attack while the third is being treated for minor injuries.
France’s interior minister Bernard Cazeneuve is en route to Arras, 115 miles north of Paris, where the train stopped after the attack.