Seven people have died from overdoses in the Cleveland area, prompting warnings from authorities.
The outbreak across Cuyahoga County comes after 52 people died from heroin or fentanyl in August.
The county medical examiner says there is no evidence yet linking the seven deaths which occurred on Saturday.
Medical examiner Thomas Gilson says his office is conducting tests to figure out which drugs were involved in the deadly overdoses.
He says the number clearly raises the possibility of a very deadly drug in the Cleveland area.
The wave of deaths follows outbreaks of overdoses in Akron and Cincinnati involving the animal sedative carfentanil.