Four explosions went off in a predominantly Shiite suburb of the capital Damascus, Syrian state TV reported.
The TV had no immediate details but the pro-government Ad-Dunya TV station said the blasts on Sunday in Sayyida Zeinab killed and wounded a "large number" of people.
The Lebanon-based Al-Mayadeen TV says the blasts occurred near a Shiite hospital in the suburb just south of Damascus. Hezbollah's Al-Manar TV reports two blasts near al-Sadr hospital, saying they inflicted casualties.
Sayyida Zeinab is home to one of Shiite Islam's holiest shrines.
The blasts came hours after two explosions in the central city of Homs killed and wounded scores of people.
A triple explosion in Sayyida Zeinab killed 45 people last month.