Japan has announced its first death from a new coronavirus from China, hours after confirming 44 more cases on a cruise ship quarantined near Tokyo.
It comes as fears of the spreading disease, officially named Covid-19 by the World Health Organisation, mount in the country.
Health minister Katsunobu Kato said the first fatality is a woman in her eighties who had been in hospital since February 1 when she was diagnosed with pneumonia.
Her confirmed diagnosis came after her death, he said.
The woman, a resident of Kanagawa prefecture near Tokyo, was the mother-in-law of a taxi driver who also became a newly confirmed case, Japanese media reported.
Health Ministry officials declined to confirm a relationship at the request of her family.
Officials also confirmed two other cases, a doctor in his fifties who works at a hospital in western Japan and a man in his twenties who lives in Chiba, near Tokyo.
None had a record of travelling abroad in recent weeks or contacts with Chinese – a possible sign that the virus is spreading inside the country.
Earlier, Mr Kato announced 44 new cases on the Diamond Princess, which is still carrying nearly 3,500 passengers and crew members.
The ship now has 218 people infected with the virus out of 713 tested since it entered Yokohama Port on February 3, the largest cluster of infections outside China.
In all, Japan has 250 confirmed cases of the new disease that apparently started in Wuhan, a city in central China, in December.
China has reported 1,367 deaths among 52,526 cases on the mainland.
Two other locations outside the mainland, Hong Kong and the Philippines, have recorded one death each.
Mr Kato said five of the patients sent to hospitals earlier have severe symptoms and are on artificial respirators or in intensive care.
The government has decided to allow passengers older than 80 to get off the ship after testing negative for the virus, Mr Kato said.
He said results of tests on about 200 eligible passengers are under way, and those with chronic health problems or in cabins without operable windows will be given priority.
Mr Kato said the measure is to reduce health risks for passengers stuck in rooms under difficult conditions.
Those who are released will be asked to stay at a designated facility through to the end of the quarantine period.
“We are doing our utmost for the health of crew members and passengers who remain on the ship,” Mr Kato told a news conference.
Some experts have questioned Japan’s strategy of isolating the passengers and crew in a potentially virus-affected environment on the ship while the disease is already slowly making its way into the country.
“On the ship, infections are getting very dense. It now provides a favourable environment for the virus to spread and I think it’s time for people to get off,” said Shigeru Omi, an infectious disease prevention expert and former regional director for the World Health Organisation.
“It’s like we are seeing a very condensed version of what could happen in a local community.”
Mr Omi, who currently heads the Japan Community Health Care Organisation, said those people who have tested positive for the virus are “only a fraction” of what could already be spreading outside of the ship.
“We should assume that the virus has already been spreading in Japan,” he said.
Prime Minister Shinzo Abe announced a 15.3 billion yen (£106 million) economic package to fight the virus, including funding for the development of vaccines and virus test kits, support for hundreds of returnees from Wuhan and measures to strengthen border controls to minimise the spread of the virus in the country.