A body has been recovered from the collapsed boiler house at Didcot power station.
The families of three men missing since the disaster in February have been informed of the discovery on Wednesday, Thames Valley Police said.
The person has not yet been formally identified.
Demolition workers Ken Cresswell, 57, and John Shaw, 61, both from Rotherham, South Yorkshire, and Chris Huxtable, 34, from Swansea, have been missing since the building in Oxfordshire partially collapsed around six months ago.
A spokesman for Thames Valley Police said: "The safe recovery of the body will take place and the disaster victim identification process will commence.
"The person has not yet been formally identified and this will be a matter for the coroner.
"Our thoughts remain with the families of the missing men and we would ask that their privacy is respected during this incredibly difficult time."
The body of Michael Collings, 53, who was also killed by the disaster, has previously been recovered from the wreckage.
The building was previously too unstable to be approached and a 50-metre exclusion zone was set up around the site.
Ken Cresswell's family seen arriving at Didcot Power Station. Not confirmed which of the 3 men has been foundpic.twitter.com/91uSR7JSiX— Global's Newsroom (@GlobalsNewsroom) August 31, 2016