Air strikes on rebel-held districts of Syria's contested city of Aleppo, including one that struck near a hospital, have killed 15 civilians and wounded many others, as fighting in the country's largest city intensified once again, opposition activists said.
The northern city has seen an uptick in violence in the last two days, with government forces pounding rebel-held eastern parts of the city with air strikes while rebels are shelling western, government-held districts.
The activists said one of Wednesday's strikes hit near the Bayan hospital in the rebel-held Shaar neighbourhood, killing 10 people. Videos uploaded on the internet by activists show massive destruction, fires and thick black smoke billowing from buildings.
Wounded people are seen being loaded into ambulances. A body covered in thick grey dust is lying face down on a street littered with debris.
The Independent Doctors Association, which describes itself as a cross-border Syrian humanitarian organisation providing health care to the province and the city of Aleppo, said on its Twitter account that an air strike hit a children's hospital it runs, destroying one floor.
The Syrian Observatory for Human Rights, a Britain-based opposition monitoring group, said 10 civilians were killed in Wednesday's attack, including children. It said the air strike hit a motorcycle repair shop in a square near the hospital. Five other civilians were killed in strikes that hit nearby districts, bringing the death toll to 15.
The Local Coordination Committees, an activist-run network, and volunteer first responders said the air strikes resulted in multiple casualties.
Hospitals and medical facilities have been regularly targeted in Syria's civil war, now in its sixth year. Since the start of the conflict in 2011, nearly 740 doctors and staff have been killed in more than 360 attacks on hospitals in Syria, according to Physicians for Human Rights.
Doctors Without Borders, known by its French acronym, MSF, says at least 100 staff members, patients and caretakers were killed, and at least 130 were wounded, in aerial bombing and shelling attacks on more than 80 MSF-supported and run health structures in 2015 and early 2016.
On April 27, an air strike widely believed to have been carried out by the Syrian government
destroyed the al-Quds hospital in Aleppo, killing a paediatrician and dozens of colleagues, patients and other civilians.
Aleppo, once Syria's thriving commercial centre, has been divided and subject to a war of attrition between government and opposition forces since the summer of 2012.
North of Aleppo, rebels broke an Islamic State siege on their stronghold of Marea, reopening the road linking the town to the Turkish border, activists said.
The Observatory said IS withdrew from several villages near Marea, redeploying fighters to the area west of the IS-held town of Manbij, where the extremists are trying to fend off an advance by Kurdish-led and US-backed forces.