Promoter Frank Warren is hosting a press conference at Upton Park next Tuesday, with reports suggesting David Haye and Dereck Chisora could be set to square-up.
The British heavyweights notoriously traded blows in Munich in February, when they violently clashed at a press conference following Chicora's loss to Vitali Klitschko.
The fall-out was a messy one, with Chisora having his license rescinded by the British Boxing Board of Control while Haye, who is technically retired, was largely unrepentant.
But quotes attributed to Warren last night indicated a match-up could be on the cards, with the media set to assemble at West Ham's home ground next Tuesday to find out more.
"It's a natural fight, it doesn't matter what anyone says," Warren reportedly said in quotes carried by a number of websites.
"It's a bigger fight than either of them fighting Wladimir or Vitali Klitschko.
"There's a lot for them to fight about - in a proper environment.
"I do see the fight happening. It's the proper forum for them to settle their differences."
It is thought Warren will confirm Kevin Mitchell and Ricky Burns as his next big promotion, although it now seems there could be another domestic bout to announce.
Chisora himself has revealed his desire to return to the ring, with his appeal against his suspension set to be heard on May 14.
And, in an interview with ITV London yesterday, the 28-year-old did not rule out meeting former WBA champion Haye.
"I'm not banned - I'm not fit enough to hold a licence. Banned means you've been banned. But when you're not fit enough that means you're not fit," he said.
"I'm a boxer, I'm a fighter. I love fighting. Someone takes something you love, how are you gonna survive and progress in your life? I wanna fight again."
When asked if he wanted to fight Haye in particular, he said: "I want to fight everybody."
Although they had no obvious rivalry, relations between the pair turned sour when Haye walked into the post-fight press conference following Chicora's gallant points defeat to Vitali Klitschko.
Initially there to lure the Ukrainian into fighting him, Haye soon became embroiled in a heated argument with Chisora, with the Zimbabwe-born fighter taunting him about his defeat to Vitalise brother Wladimir last year.
Punches were then thrown and a tripod was wielded in scenes that shocked the boxing world.
Spokesmen for both fighters were unavailable for comment when contacted by Press Association Sport.