Garry Ringrose and Tadhg Furlong have returned from injury to start for Ireland against Scotland in Saturday's Six Nations clash, writes Stephen Barry.
However, Iain Henderson misses out on a starting spot in Joe Schmidt's team, but is fit enough to take his place on the bench behind James Ryan and Devin Toner.
Ringrose replaces man-of-the-match against Wales Chris Farrell, Ireland's second outside centre to be ruled out of the tournament after Robbie Henshaw's shoulder injury.
Furlong's return to tighthead prop sees Andrew Porter return to the bench, with John Ryan losing his place among the replacements.
Quinn Roux, Jack Conan and Fergus McFadden also drop out of the matchday 23, replaced by Henderson, Jordi Murphy, who is in line to make his first Ireland appearance of the championship, and Jordan Larmour.
Ireland team v Scotland:
15. Rob Kearney (UCD/Leinster) 81 caps
14. Keith Earls (Young Munster/Munster) 65 caps
13. Garry Ringrose (UCD/Leinster) 11 caps
12. Bundee Aki (Galwegians/Connacht) 5 caps
11. Jacob Stockdale (Ballynahinch/Ulster) 7 caps
10. Johnny Sexton (St Mary’s College/Leinster) 71 caps
9. Conor Murray (Garryowen/Munster) 62 caps
1. Cian Healy (Clontarf/Leinster) 76 caps
2. Rory Best (Banbridge/Ulster) 109 caps
3. Tadhg Furlong (Clontarf/Leinster) 21 caps
4. James Ryan (UCD/Leinster) 6 caps
5. Devin Toner (Lansdowne/Leinster) 56 caps
6. Peter O’Mahony (Cork Constitution/Munster) 45 caps
7. Dan Leavy (UCD/Leinster) 7 caps
8. CJ Stander (Shannon/Munster) 21 caps
16. Sean Cronin (St Mary’s College/Leinster) 59 caps
17. Jack McGrath (St Mary’s College/Leinster) 45 caps
18. Andrew Porter (UCD/Leinster) 5 caps
19. Iain Henderson (Ballynahinch/Ulster) 36 caps
20. Jordi Murphy (Lansdowne/Leinster) 18 caps
21. Kieran Marmion (Corinthians/Connacht) 19 caps
22. Joey Carbery (Clontarf/Leinster) 8 caps
23. Jordan Larmour (St Mary’s College/Leinster) 1 cap