Brendan Rodgers handed Luis Suarez the captain’s armband for the first time as Liverpool looked to earn a morale-boosting win at Tottenham.
Lucas replaced regular skipper Steven Gerrard in the only change from the XI that beat West Ham 4-1 last weekend.
Roberto Soldado kept his place in the Spurs team after scoring a hat-trick against Anzhi Makhachkala.
There were seven changes in total from the game against the Russians.
Tottenham: Lloris, Walker, Capoue, Dawson, Naughton, Sandro, Dembele, Lennon, Paulinho, Chadli, Soldado.
Subs: Lamela, Holtby, Townsend, Defoe, Sigurdsson, Friedel, Fryers.
Liverpool: Mignolet, Johnson, Skrtel, Sakho, Flanagan, Lucas, Allen, Henderson, Coutinho, Sterling, Suarez.
Subs: Brad Jones, Toure, Agger, Alberto, Aspas, Moses, Kelly.
Referee: Jon Moss (W Yorkshire)