Dylan Hartley, Chris Ashton and Manu Tuilagi have been named in England’s squad for the RBS 6 Nations, but the 33-man party includes a number of big-name omissions.
Tom Youngs, Tom Wood, Geoff Parling and Danny Cipriani have all missed out on selection in the first group to be named by new head coach Eddie Jones.
In total there are seven uncapped players with Sam Hill, Josh Beaumont, Jack Clifford, Elliot Daly, Ollie Devoto, Paul Hill and Maro Itoje featuring.
Tuilagi returns to the squad after missing last autumn's World Cup for disciplinary and injury reasons, but last Saturday the centre made his comeback after 15 months out with a groin problem.
Devoto is present as an injury replacement for Tuilagi, enabling England to call upon their British and Irish Lions wrecking ball for the latter stages of the Six Nations once he has proved his fitness at the Tigers.
“We will be without Manu for the Scotland game but we will continue to work with Leicester and Manu and see where he is as the Six Nations progresses,” Jones said.
“With big European weekends ahead there may be further changes once we assess the fitness of the players.”
Joining Tom Youngs, Wood and Parling among the players who appeared at last autumn's World Cup but who have been overlooked are Rob Webber, Brad Barritt, Nick Easter, David Wilson, Ben Morgan and Richard Wigglesworth.
The changes represent radical surgery to the squad selected by Jones’ predecessor Stuart Lancaster, but Chris Robshaw is still present. Jones is due to name his captain on January 25 or 26.
Flanker Matt Kvesic, prop Henry Thomas and centre Sam Hill have been included as injury replacements for Dave Ewers, Kieran Brookes and Henry Slade respectively.
“I have spoken to some of the players who have not been selected. Naturally they will be disappointed and that is how it should be,” Jones said.
“They know what they need to do to get back into this squad. The door is not shut for anyone. There is no such thing as a shut door because of injuries and loss of form.
“There will always be opportunities to anyone playing consistently well in the Premiership and Europe.
“I am really excited about working with England and together with (coaches) Steve (Borthwick) and Paul (Gustard) we hope to build a team that will reflect the level of talent that exists within the English game.”